Formulated with neurologist-recommended ingredients and designed to support consistent, daily use, 3graine is Canada's leading 3-in-1 headache relief.
Stop migraine before it starts
DAILY MIGRAINE PREVENTION SUPPLEMENT
Clinically-Backed
Third-party tested
Health Canada Authorized
Neurologist-Recommended
Made in Canada
Evidence-Based Support
3-in-1 Formula
Formulated using clinical experience.
Neurologists and health-care professionals routinely recommend patients to trial Magnesium, Riboflavin (B2), and CoQ10 for migraine prevention.
The Problem:
• Three separate supplements
• Multiple doses every day
• A daily routine that's hard to maintain
But 3graine was developed to solve this.
It combines all three neurologist-recommended supplements into one single daily dose of 3 capsules.
Developed from real clinical experience — so patients can actually give the supplements a try.
An innovative, patient-
centered formulation.
By reducing pill and product burden, 3graine supports long-term adherence and consistent outcomes over time.
Most clinical benefit is typically observed after 2-3 months of consistent use.
Prevent Reduce Relieve Migraine
EXPERT RECOMMENDED • EVIDENCE-BASED • EFFICACY-DRIVEN
VITAMIN B2 (400MG)
400mg daily shown in trials to reduce migraine frequency by up to 50% within 3–4 months.
Supports cellular energy production and helps reduce oxidative stress both linked to migraine activity
MAGNESIUM (300MG)
Supports neurotransmitters and vascular tone; up to 50% of migraine sufferers are deficient
Helps regulate nerve signaling and supports normal neurological function
COENZYME Q10 (200MG)
Clinical studies show benefits at 100–300mg daily with consistent use over 3+ months
Helps regulate nerve signaling and supports normal neurological function
Featured product
3graine Daily Migraine Prevention
Canada’s 3-in-1 headache pain relief supplement with 3 neurologist-recommended ingredients & doses in one.
Prevent migraine with 3 easy-to-take capsules per day.
Made & Authorized for Sale in Canada
Choosing Your Prevention Protocol
Long-term Prevention Pack
MOST RECOMMENDED
BEST VALUE
Research recommends consistent use for 2–3 months
How do I use 3graine?
For best results, take three-capsules of 3graine per day. Capsules can be taken at once or split throughout day. Consistency is most important.
For those with supplement/medication sensitivities, we suggest starting with one-capsule per day, working up to the full dose.
Capsules can be opened and mixed with foods like yogurt or other high fat foods.
Ingredients
Medical Ingredients (per capsule):
• Vitamin B2 (Riboflavin) - 133.33mg
• Magnesium (Citrate) - 100mg
• Coenzyme Q10 (CoQ10) - 66.57mg
Non-medical Ingredients:
• Hypromellose
• Magnesium Stearate
• Microcrysatline Cellulose
Vegan, GMO-Free, Gluten Free.
Side Effects
As with any supplement, minor side effects may be seen by some users in their first few weeks of taking 3graine.
Most side effects improve after a few weeks of consistent use. Research studies support this as well.
Common side effects can include:
• Changes in urine color (from B2)
• Mild digestive changes
If needed, start with one daily capsule, working up to the full dose.
Testing & Authorization
3graine is made, and third-party tested in Canada. It's important to know that you are actually getting what you are buying. We've made it a priority that what is stated on the label is what you get.
Authorized for Sale by Health Canada
Did you know?
Just 3 daily capsules is all it takes.
It takes an average of 8 daily capsules to meet the same neurologist-recommended guidelines that 3graine delivers in 3.
Migraine?
Think
Benefits that build over time.
Designed for daily use, replenishing your body with essential nutrients to build systemic health over time.
WEEKs 1-3
Starting Phase
In this phase, your body is adapting.
If needed, start with one capsule daily, working up to the full dose of 3.
You may notice:
⦿ Mild digestive changes
⦿ Bright yellow urine (from B2, this is normal)
Typically resolves within ~2 weeks.
Months 1-2
Early Benefit
Some users begin to notice:
↓ Fewer migraine days
↓ Reduced severity
Stay consistent, even if changes are subtle.
Prevention takes time.
Month 3+
Clinical Benefits
This is where results often become more noticeable:
✓ Reduced frequency of migraines
✓ Less disruption to daily life
✓ Improved overall consistency and control
The compounding effect is kicking in.
Track how your body is responding.
Sustained outcomes are associated with consistent use and adherence to a regular routine.
Patients are encouraged to track changes in symptom patterns, frequency, and overall function throughout use.
KEVIN LE, CCPA
CLINICAL EXPERIENCE MEETS INNOVATION
Meet the Founder
Kevin, a Canadian-trained Physician Assistant specializing in neurology, has focused his career on improving access to care for patients with headache disorders, including migraine and epilepsy.
His work contributed to clinical programs adopted by institutions such as The Hospital for Sick Children and to Ontario Health’s first virtual neurology care policy.
Frequently asked
questions:
The daily dose is 3 capsules, which can be taken all at once or split throughout the day. If you are sensitive to supplements or medication, you may start with 1-2 capsules per day and gradually increase to 3 capsules over a few weeks.
Capsules can be opened.
We recommend taking 3graine with food to help reduce at gastrointestinal side effects. Most people have found 3graine to be very tolerable with minimal side effects.
Like many other supplements, 3graine may have side effects. The main side effects include changes in urine colour, loose stool, and diarrhea.
Research studies have shown that if you experience loose stool or diarrhea, it will likely improve after a few weeks of continuous use. If side effects persist, we recommend discontinuing use.
The 3 capsule dose can help to split the dosing throughout the day as well as help more sensitive users titrate up to the recommended dose.
Despite what other products may claim, it is not possible to put the 3 neurologist-recommended ingredients and doses into 2 capsules (we tried). With 3graine, you can be sure that you are getting what you are buying.
Most people who benefit will begin to see a response around 2-3 months of consistent use.
Proud sponsor & partner of Migraine Canada®
A portion of every sale goes to support research & initiatives to help improve the lives of Canadians living with headaches and migraine.
Made in Canada
Authorized by Health Canada
Third-Party Tested
Stop migraine before it starts
Prevent migraine with Canada's leading
3-in-1 supplement for migraine and headache relief.
Free shipping on orders over $50
Shop now, pay later
Free shipping on orders over $50
Shop now, pay later
Free shipping on orders over $50
Shop now, pay later
Free shipping on orders over $50
Shop now, pay later